Mood Stabilizer Vs Third Generation Antipsychotic: A Double-Blind Clinical Trial in Acute Mania_ Crimson Publishers
Mood Stabilizer Vs Third Generation Antipsychotic: A Double-Blind Clinical Trial in Acute Mania by Shoja Shafti S in Integrative Journal of Conference Proceedings Abstract Objective: While prescription of lithium has been limited in recent years due to its adverse effects and necessity for frequent laboratory tests, second generation antipsychotics (SGAs) are introduced as helpful medications for acute and maintenance treatment of bipolar disorder. Comparing lithium with aripiprazole in a group of patients with diagnosis of acute mania was the objective of the present trial. Methods: 30 male inpatients with diagnosis of bipolar I disorder were entered into a four-week, doubleblind study for random assignment to lithium carbonate (800-1200mg/day) or aripiprazole (20-30mg/ day) (n=15 in each group). While Manic State Rating Scale (MSRS) was the main outcome measure in the present assessment, other scales such as Bech-Rafaelsen Mania Scale (BRMS), Schedule for Assessment of Ins...